Hydrochloric Acid → 4-{4-[(Cyclohexyloxy)carbonyl]-1,3-thiazol-2-yl}piperidinium chloride

HRID 1047333Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1047333
[ClH:1].[CH:2]1([O:8][C:9]([C:11]2[N:12]=[C:13]([CH:16]3[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]3)[S:14][CH:15]=2)=[O:10])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1>C(OCC)C.O1CCOCC1>[Cl-:1].[CH:2]1([O:8][C:9]([C:11]2[N:12]=[C:13]([CH:16]3[CH2:17][CH2:18][NH2+:19][CH2:20][CH2:21]3)[S:14][CH:15]=2)=[O:10])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 44469190tert-Butyl 4-{4-[(cyclohexyloxy)carbonyl]-1,3-thiazol-2-yl}piperidine-1-carboxylate

Produkt 1

HCID 669115194-{4-[(Cyclohexyloxy)carbonyl]-1,3-thiazol-2-yl}piperidinium chloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

Under argon and at 0° C., a 2-molar solution of hydrogen chloride in diethyl ether (50 ml) is added dropwise to a solution of tert-butyl 4-{4-[(cyclohexyloxy)carbonyl]-1,3-thiazol-2-yl}piperidine-1-carboxylate (IX-1, 2.63 g) in dioxane (20 ml). The reaction mixture is stirred at 0° C. and then slowly warmed to room temperature. After stirring overnight, the solvent and excess hydrogen chloride are removed. This gives 4-{4-[(cyclohexyloxy)carbonyl]-1,3-thiazol-2-yl}piperidinium chloride (2.19 g, 99%)

Aufarbeitung

  1. temperatureslowly warmed to room temperature
  2. stirringAfter stirring overnight
  3. customthe solvent and excess hydrogen chloride are removed

Quellen und Nachweise

ORD-Eintrag
ord-d005a88193c740ff99d644027813555d
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08569509B2

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