Water → 2-(2-Isobutyryl-3-methyl-benzoylamino)-indan-2-carboxylic acid

HRID 1047849Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1047849
C([O:3][C:4]([C:6]1([NH:15][C:16](=[O:29])[C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([CH3:23])[C:18]=2[C:24](=[O:28])[CH:25]([CH3:27])[CH3:26])[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7]1)=[O:5])C.[OH-].[K+].O>CCO>[C:24]([C:18]1[C:19]([CH3:23])=[CH:20][CH:21]=[CH:22][C:17]=1[C:16]([NH:15][C:6]1([C:4]([OH:5])=[O:3])[CH2:7][C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:14]1)=[O:29])(=[O:28])[CH:25]([CH3:27])[CH3:26]

Komponenten

5

Edukt 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 593142722-(2-Isobutyryl-3-methyl-benzoylamino)-indan-2-carboxylic acid ethyl ester

Produkt 1

HCID 251609222-(2-Isobutyryl-3-methyl-benzoylamino)-indan-2-carboxylic acidAusbeute 89,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

The mixture of 2-(2-isobutyryl-3-methyl-benzoylamino)-indan-2-carboxylic acid ethyl ester (228) (170 mg, 0.43 mmol) and KOH (500 mg, 8.9 mmol) is dissolved in EtOH (20 mL) and water (1 mL) under a water bath. The water bath is removed when KOH is completely dissolved and the resulting reaction solution is stirred at RT for 8 h. After concentration in vacuo, the residue is dissolved in water (20 mL) and acidified with conc. HCl until no more precipitate came out of the water. The precipitate is filtered to give a pure product (229) as white solid (140 mg, 89%).

Aufarbeitung

  1. customThe water bath is removed when KOH
  2. dissolutionis completely dissolved
  3. customthe resulting reaction solution
  4. concentrationAfter concentration in vacuo
  5. dissolutionthe residue is dissolved in water (20 mL)
  6. filtrationThe precipitate is filtered

Quellen und Nachweise

ORD-Eintrag
ord-86f149f7b548467cb3370a0d143b902d
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08569535B2

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