Ethanol → HCID 25161047, Verbindung

HRID 1047855Notizen

Reaktionsgleichung

C([O:3][C:4]([C:6]1([NH:15][C:16](=[O:26])[C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]#[N:24])[C:18]=2[CH3:25])[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7]1)=[O:5])C.[OH-].[K+].CCO>O>[C:23]([C:19]1[C:18]([CH3:25])=[C:17]([CH:22]=[CH:21][CH:20]=1)[C:16]([NH:15][C:6]1([C:4]([OH:5])=[O:3])[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7]1)=[O:26])#[N:24]

Komponenten

Reaktionsbedingungen

Temperatur: 50 °C

Versuchsvorschrift

The mixture of 2-(3-cyano-2-methyl-benzoylamino)-indan-2-carboxylic acid ethyl ester (3) (310 mg, 0.89 mmol), KOH (50% aqueous solution, 2 g, 17.8 mmol), EtOH (10 mL) and water (1 mL) are stirred in a 20 mL vial at 50° C. for 30 min. After concentration in vacuo, the residue is dissolved in water (5 mL) and acidified with conc. HCl until no more white precipitate came out of the water. The filtration affords 2-(3-cyano-2-methyl-benzoylamino)-indan-2-carboxylic acid (238) as white solid (270 mg, 95%).

Aufarbeitung

concentrationAfter concentration in vacuo
dissolutionthe residue is dissolved in water (5 mL)
filtrationThe filtration

Quellen und Nachweise

ORD-Eintrag: ord-7e9508a68ee94dfe9341de8d24d8de57
Quelldatensatz: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08569535B2

Notizen zur Reaktion

Wird geladen…