Methanol → 2-Methoxypyridine-3-carbonitrile

HRID 1048743

Reaktionsgleichung

Reaktionsgleichung von HRID 1048743
[Na].[CH3:2][OH:3].Cl[C:5]1[N:12]=[CH:11][CH:10]=[CH:9][C:6]=1[C:7]#[N:8]>O>[CH3:2][O:3][C:5]1[N:12]=[CH:11][CH:10]=[CH:9][C:6]=1[C:7]#[N:8]

Komponenten

5

Edukt 3

HCID 887MethanolHCID 810792-ChloronicotinonitrileHCID 5360545Sodium

Produkt 1

HCID 2520992-Methoxypyridine-3-carbonitrileAusbeute 81 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

4.98 g (217 mmol) of sodium is added to 80 ml of anhydrous methanol. The reaction medium is stirred at room temperature for 10 minutes and then 10 g (72.2 mmol) of 2-chloronicotinonitrile is added at 0° C. The reaction medium is stirred at 25° C. for 16 hours. The reaction is hydrolyzed by slowly adding water at 0° C. After returning to room temperature, the precipitate obtained is filtered, rinsed with water and then dried at 50° C. to yield 7.85 g (81%) of 2-methoxy-nicotinonitrile in the form of a yellow solid.

Aufarbeitung

  1. stirringThe reaction medium is stirred at 25° C. for 16 hours
  2. customAfter returning to room temperature
  3. customthe precipitate obtained
  4. filtrationis filtered
  5. washrinsed with water
  6. customdried at 50° C.

Quellen und Nachweise

ORD-Eintrag
ord-92c99cd601214552a04f44e26321ed1b
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09381195B2

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