Ammonia → 3-Amino-6-iodopyrazine-2-carboxamide

HRID 1048747

Reaktionsgleichung

Reaktionsgleichung von HRID 1048747
[NH3:1].[NH2:2][C:3]1[C:4]([C:10]([O:12]C)=O)=[N:5][C:6]([I:9])=[CH:7][N:8]=1>O.CO>[NH2:2][C:3]1[C:4]([C:10]([NH2:1])=[O:12])=[N:5][C:6]([I:9])=[CH:7][N:8]=1

Komponenten

5

Edukt 2

HCID 222AmmoniaHCID 11087124Methyl 3-amino-6-iodopyrazine-2-carboxylate

Produkt 1

HCID 468639523-Amino-6-iodopyrazine-2-carboxamideAusbeute 88 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

30 ml of ammonia in water is added under magnetic stirring to 15 g (53.8 mmol) of a solution of methyl 3-amino-6-iodopyrazine-2-carboxylate in 150 ml of methanol. The reaction medium is stirred at 25° C. for 48 hours. After evaporation of the solvents, the precipitate obtained is filtered, rinsed with water and then dried at 50° C. to yield 12.50 g of 3-amino-6-iodopyrazine-2-carboxamide (88%) in the form of a beige solid.

Aufarbeitung

  1. customAfter evaporation of the solvents
  2. customthe precipitate obtained
  3. filtrationis filtered
  4. washrinsed with water
  5. customdried at 50° C.

Quellen und Nachweise

ORD-Eintrag
ord-c0216cb74b3e402989679dfb81b04b3b
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09381195B2

Verknüpfte Notizen

Wird geladen…