Triethylamine → HCID 131736029, Verbindung

HRID 1049568

Reaktionsgleichung

Reaktionsgleichung von HRID 1049568
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][O:9][CH2:10][O:11][CH3:12])[CH:3]=1.C(N(CC)CC)C.C1(C)C=CC=CC=1P(C1C=CC=CC=1C)C1C=CC=CC=1C.[C:42]([O:46][CH2:47][CH3:48])(=[O:45])[CH:43]=[CH2:44]>CN(C=O)C.C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[CH3:12][O:11][CH2:10][O:9][CH2:8][C:4]1[CH:3]=[C:2](/[CH:44]=[CH:43]/[C:42]([O:46][CH2:47][CH3:48])=[O:45])[CH:7]=[CH:6][CH:5]=1

Komponenten

7

Edukt 4

HCID 8471TriethylamineHCID 8821Ethyl AcrylateHCID 80271Tri-o-tolylphosphineHCID 114475781-Bromo-3-[(methoxymethoxy)methyl]benzene

Produkt 1

HCID 131736029HCID 131736029, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 167845palladium(II) acetateKatalysatorHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

Under a nitrogen atmosphere, a crude product of 1-bromo-3-((methoxymethoxy)methyl)benzene (3.60 g), triethylamine (6.50 mL), palladium acetate (175 mg), tri-o-tolylphosphine (711 mg) and ethyl acrylate (8.4 mL) were stirred in DMF (30 mL) at 110° C. for 1 hr. The solvent of the reaction mixture was evaporated under reduced pressure and the residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane) to give the title compound (3.41 g) as a pale-yellow oil.

Aufarbeitung

  1. customThe solvent of the reaction mixture was evaporated under reduced pressure
  2. customthe residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane)

Quellen und Nachweise

ORD-Eintrag
ord-cea30461553949a49694e8212e9a80e1
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09382188B2

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