Hydrochloride methanol → N-[(1-Amino-5-isoquinolyl)sulfonyl]-N-[2-(phenylsulfonyl)ethyl]ethylenediamine hydrochloride

HRID 10500Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 10500
[NH2:1][C:2]1[C:11]2[C:6](=[C:7]([S:12]([N:15]([CH2:26][CH2:27][S:28]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)(=[O:30])=[O:29])[CH2:16][CH2:17][NH:18]C(OC(C)(C)C)=O)(=[O:14])=[O:13])[CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1.[ClH:37].CO>C(OCC)C>[ClH:37].[NH2:1][C:2]1[C:11]2[C:6](=[C:7]([S:12]([N:15]([CH2:26][CH2:27][S:28]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)(=[O:30])=[O:29])[CH2:16][CH2:17][NH2:18])(=[O:13])=[O:14])[CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1

Komponenten

4

Edukt 2

HCID 21893726Hydrochloride methanolHCID 21979800N-[(1-amino-5-isoquinolyl)sulfonyl]-N'-(tert-butoxycarbonyl)-N-[2-(phenylsulfonyl)ethyl]ethylenediamine

Produkt 1

HCID 21979847N-[(1-Amino-5-isoquinolyl)sulfonyl]-N-[2-(phenylsulfonyl)ethyl]ethylenediamine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

According to the method of Example 1, Step C, deprotection was performed (50° C., 2 hours) by using Intermediate 17 (134 mg) and 10% hydrogen chloride/methanol solution (2.5 ml). The reaction mixture was cooled to room temperature and then added with diethyl ether (2.5 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (100 mg) as white powdery solid.

Aufarbeitung

  1. custom(50° C., 2 hours)
  2. customThe deposited precipitates
  3. filtrationwere collected by filtration
  4. washwashed with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-cfd70b3b3b30460cbdf9d354bc36adca
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07094789B2

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