Acetic Acid → 1,3-Bis(1-methylethoxy)-2-propanol

Temperatur

80 °C

2-(Isopropoxymethyl)oxirane (23.23 g, 25.1 mL, 200 mmol) was dissolved in hexane (20 mL) and placed in reactor. Separately (1.2 g, 20 mmol) of KH was slowly added to (90.1 g, 115 mL, 1.5 Mol) of isopropanol at RT. After deprotonation was complete the solution of potassium isopropoxide in isopropanol was added to the reactor. All operations were performed in a glove box. The reactor was sealed and heated 80° C. for 24 hours. After cooling acetic acid (20 mmols) and ca. 5 g. of powdered talc were added to the reaction mixture followed by filtration through a plug of celite. The solvent was evaporated and the residue distilled under vacuum affording 20.09 g of 1,3-diisopropoxypropan-2-ol.

1. customplaced in reactor
2. additionwas added to the reactor
3. customAll operations were performed in a glove box
4. customThe reactor was sealed
5. filtrationfollowed by filtration through a plug of celite
6. customThe solvent was evaporated
7. distillationthe residue distilled under vacuum

ORD-Eintrag

ord-058682eadab8481ea18e4183af0407f7

Quelldatensatz

uspto-grants-2016_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09388106B2