(3-tert-Butoxycarbonylamino-cyclobutylidene)-acetic acid methyl ester → HCID 54100600, Verbindung

HRID 1050942Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1050942
[CH3:1][O:2][C:3](=[O:17])[CH:4]=[C:5]1[CH2:8][CH:7]([NH:9][C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:6]1>CO.[Pd]>[CH3:1][O:2][C:3](=[O:17])[CH2:4][CH:5]1[CH2:6][CH:7]([NH:9][C:10]([O:12][C:13]([CH3:15])([CH3:14])[CH3:16])=[O:11])[CH2:8]1

Komponenten

4

Edukt 1

HCID 23374583(3-tert-Butoxycarbonylamino-cyclobutylidene)-acetic acid methyl ester

Produkt 1

HCID 54100600HCID 54100600, VerbindungAusbeute 99,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of (3-tert-Butoxycarbonylamino-cyclobutylidene)-acetic acid methyl ester (7 g, 29 mmol) in methanol (100 mL) was added Pd/C (5 g) and stirred at room temperature under H2 balloon overnight. After TLC showed the reaction was completed, the mixture was filtered over Celite. The filtrate was concentrated under reduced pressure to give the title compound (7 g, yield 99%) as a white solid, which was used for the next step directly without further purification.

Aufarbeitung

  1. filtrationthe mixture was filtered over Celite
  2. concentrationThe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-bf2a244da6e34fc8ab3726c56f5036df
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09388141B2

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