Water → (R)-1-((2,2-Dimethyl-1,3-dioxolan-4-yl)methyl)-1H-pyrazol-3-amine

HRID 1051204Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1051204
[CH3:1][C:2]1([CH3:20])[O:6][C@H:5]([CH2:7][N:8]2[CH:12]=[CH:11][C:10]([NH:13]C(=O)C(C)(C)C)=[N:9]2)[CH2:4][O:3]1.O.[OH-].[Na+]>CO>[CH3:1][C:2]1([CH3:20])[O:6][C@H:5]([CH2:7][N:8]2[CH:12]=[CH:11][C:10]([NH2:13])=[N:9]2)[CH2:4][O:3]1

Komponenten

5

Edukt 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 90258498HCID 90258498, Verbindung

Produkt 1

HCID 59344941(R)-1-((2,2-Dimethyl-1,3-dioxolan-4-yl)methyl)-1H-pyrazol-3-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

N-[1-((R)-2,2-Dimethyl-[1,3]dioxolan-4-ylmethyl)-1H-pyrazol-3-yl]-2,2-dimethyl-propionamide (1.42 g, 5 mmol) was dissolved in methanol (15 ml), and water (3 ml) was added in one portion. NaOH (1.67 g, 40 mmol) was added in one portion. The mixture was stirred at 70° C. for 40 h. HPLC indicated the conversation was 2.8%. No further workup.

Quellen und Nachweise

ORD-Eintrag
ord-f508cd2590294f33a90ac789ea575d8b
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09388168B2

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