Bromine → N-(4-bromo-2-methylthiazol-5-yl)acetamide

To a solution of N-(2-methylthiazol-5-yl)acetamide (0.4 g, 2.6 mmol) in CHCl3 (30 mL) was added Br2 (0.15 mL, 2.8 mmol), then the solution was stirred at room temperature for 12 h to give a brown solution. The reaction mixture was diluted with saturated NaHSO3 solution. The aqueous layer was extracted with DCM (3×30 mL). The combined organic layers were dried with Na2SO4, filtered and concentrated to afford a yellow solid. The resulting mixture was deposited onto silica gel and loaded onto a silica gel column and eluted with PE/EA(1:1) to give the title compound (400 mg, yield 67%).

1. customto give a brown solution
2. extractionThe aqueous layer was extracted with DCM (3×30 mL)
3. dry with materialThe combined organic layers were dried with Na2SO4
4. filtrationfiltered
5. concentrationconcentrated
6. customto afford a yellow solid
7. washeluted with PE/EA(1:1)

ORD-Eintrag

ord-432fd5a06d8249868afbdf458b1a3e7c

Quelldatensatz

uspto-grants-2016_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09388180B2