Lithium hydroxide, monohydrate → 4,5,6,7-Tetrahydrobenzo[d]thiazole-7-carboxylic acid

HRID 1051912Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1051912
[S:1]1[C:5]2[CH:6]([C:10]([O:12]C)=[O:11])[CH2:7][CH2:8][CH2:9][C:4]=2[N:3]=[CH:2]1.O[Li].O>C1COCC1.CO.O>[S:1]1[C:5]2[CH:6]([C:10]([OH:12])=[O:11])[CH2:7][CH2:8][CH2:9][C:4]=2[N:3]=[CH:2]1

Komponenten

4

Edukt 2

HCID 168937Lithium hydroxide, monohydrateHCID 90303216Methyl 4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylate

Produkt 1

HCID 838762464,5,6,7-Tetrahydrobenzo[d]thiazole-7-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21892291Methanol tetrahydrofuran waterLösungsmittel

Versuchsvorschrift

A mixture of methyl 4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylate (1.22 g, 6.11 mmol) and LiOH.H2O (0.39 g, 9.17 mmol) in THF/MeOH/H2O (60 mL, 3:1:1) was stirred at RT for 75 min. The mixture was acidified to pH=3 and extracted with DCM. The comb. org. layers were dried over MgSO4 and conc. in vacuo to provide a yellow solid.

Aufarbeitung

  1. extractionextracted with DCM
  2. dry with materiallayers were dried over MgSO4 and conc. in vacuo
  3. customto provide a yellow solid

Quellen und Nachweise

ORD-Eintrag
ord-e6bd327a824749d392d50a9c42f6095b
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09388197B2

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