Lithium hydroxide, monohydrate → 2-Methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylic acid

HRID 1051916Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1051916
[CH3:1][C:2]1[S:3][C:4]2[CH:10]([C:11]([O:13]C)=[O:12])[CH2:9][CH2:8][CH2:7][C:5]=2[N:6]=1.O[Li].O>C1COCC1.CO.O>[CH3:1][C:2]1[S:3][C:4]2[CH:10]([C:11]([OH:13])=[O:12])[CH2:9][CH2:8][CH2:7][C:5]=2[N:6]=1

Komponenten

4

Edukt 2

HCID 168937Lithium hydroxide, monohydrateHCID 90303556Methyl 2-methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylate

Produkt 1

HCID 822769032-Methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21892291Methanol tetrahydrofuran waterLösungsmittel

Versuchsvorschrift

A mixture of methyl 2-methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylate (59 mg, 0.28 mmol) and LiOH.H2O (14 mg, 0.33 mmol) in THF/MeOH/H2O (2.5 mL, 3:1:1) was stirred at RT for 2 h. The mixture was acidified to pH=3 and extracted with EtOAc. The comb. org. layers were dried over MgSO4, and conc. in vacuo.

Aufarbeitung

  1. extractionextracted with EtOAc
  2. dry with materiallayers were dried over MgSO4

Quellen und Nachweise

ORD-Eintrag
ord-05c36b194d0f492d9a17c4ac3aa5227e
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09388197B2

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