(S)-Benzyl 4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate → HCID 90102798, Verbindung

HRID 1052583Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1052583
[CH3:1][C:2]1[CH:3]=[CH:4][N:5]2[C:10]=1[C:9](=[O:11])[N:8]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:7]([C@@H:18]([NH:20][C:21]1[C:22]3[C:29]([C:30]([O:32]CC4C=CC=CC=4)=[O:31])=[CH:28][NH:27][C:23]=3[N:24]=[CH:25][N:26]=1)[CH3:19])=[N:6]2>CO.[Pd]>[CH3:1][C:2]1[CH:3]=[CH:4][N:5]2[C:10]=1[C:9](=[O:11])[N:8]([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)[C:7]([C@@H:18]([NH:20][C:21]1[C:22]3[C:29]([C:30]([OH:32])=[O:31])=[CH:28][NH:27][C:23]=3[N:24]=[CH:25][N:26]=1)[CH3:19])=[N:6]2

Komponenten

4

Edukt 1

HCID 73775928(S)-Benzyl 4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate

Produkt 1

HCID 90102798HCID 90102798, VerbindungAusbeute 81,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 23938PalladiumLösungsmittel

Versuchsvorschrift

(S)-Benzyl 4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate (560 mg, 1.08 mmol) was dissolved in methanol (200 ml) and hydrogenated in a Parr apparatus at 25 psi in the presence of Pd/C 10%. Once the reaction was completed, the mixture was filtered and the solvent evaporated under reduced pressure to yield 376 mg (79% yield) of the final compound, which was used in the next synthetic step without further purification.

Aufarbeitung

  1. filtrationthe mixture was filtered
  2. customthe solvent evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-4078c8f8fda848b39cdcbe0e6842ad10
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09388189B2

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