Triethylamine → HCID 90103295, Verbindung

Reaktionsgleichung

[Br:1][C:2]1[CH:10]=[C:9]([NH2:11])[CH:8]=[C:7]2[C:3]=1[CH:4]=[N:5][NH:6]2.[CH3:12][S:13](Cl)(=[O:15])=[O:14].C(N(CC)CC)C>>[Br:1][C:2]1[CH:10]=[C:9]([NH:11][S:13]([CH3:12])(=[O:15])=[O:14])[CH:8]=[C:7]2[C:3]=1[CH:4]=[N:5][NH:6]2

Komponenten

Edukt 3

HCID 8471Triethylamine

HCID 31297Methanesulfonyl chloride

HCID 247280674-Bromo-1H-indazol-6-amine

Produkt 1

HCID 90103295HCID 90103295, VerbindungAusbeute 61,5 %

Versuchsvorschrift

4-Bromo-1H-indazol-6-amine (500 mg, 2.36 mmol) was treated with methanesulfonyl chloride (130 μl, 1.68 mmol) and triethylamine (49 μl, 3.55 mmol) according to the method described in Preparation 15b. The residue was purified using SP1® Purification System to give 300 mg (49% yield) of the title compound. Purity 80%.