HCID 86694092, Verbindung → HCID 86694094, Verbindung

HRID 1053476Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1053476
C([O:8][N:9]1[C:15](=[O:16])[N:14]2[CH2:17][C@H:10]1[CH2:11][CH2:12][C@H:13]2[C:18]([NH:20][NH:21][C:22]([CH:24]1[CH2:27][C:26]([F:29])([F:28])[CH2:25]1)=[O:23])=[O:19])C1C=CC=CC=1.[H][H]>CO.[Pd]>[F:29][C:26]1([F:28])[CH2:27][CH:24]([C:22]([NH:21][NH:20][C:18]([C@@H:13]2[CH2:12][CH2:11][C@@H:10]3[CH2:17][N:14]2[C:15](=[O:16])[N:9]3[OH:8])=[O:19])=[O:23])[CH2:25]1

Komponenten

5

Edukt 2

HCID 86694092HCID 86694092, VerbindungHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 86694094HCID 86694094, VerbindungAusbeute 96,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of (2S,5R)-6-(benzyloxy)-N′-[(3,3-difluorocyclobutyl)carbonyl]-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carbohydrazide 283 (0.32 g, 0.78 mml) in methanol (25 mL) was added 10% Pd/C (0.40 g). The mixture was hydrogenated under 10 psi hydrogen atmosphere at room temperature for 1 h. The catalyst was filtered out through Celite, and the filtrate was evaporated to give 284 (0.24 g, 96%) as a white foam.

Aufarbeitung

  1. filtrationThe catalyst was filtered out through Celite
  2. customthe filtrate was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-c8d6812816d048f8bf383c9157866b94
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09393239B2

Notizen zur Reaktion

Wird geladen…