Tri-o-tolylphosphine → Methyl (3S)-4-(5-amino-2-methoxy-phenyl)-3-(tert-butoxycarbonylamino)-butanoate

HRID 1053659

Reaktionsgleichung

Reaktionsgleichung von HRID 1053659
[C:1]([O:5][C:6]([NH:8][C@@H:9]([CH2:15]I)[CH2:10][C:11]([O:13][CH3:14])=[O:12])=[O:7])([CH3:4])([CH3:3])[CH3:2].I[C:18]1[CH:19]=[C:20]([CH:22]=[CH:23][C:24]=1[O:25][CH3:26])[NH2:21].C1(C)C=CC=CC=1P(C1C=CC=CC=1C)C1C=CC=CC=1C>[Zn]>[NH2:21][C:20]1[CH:19]=[CH:18][C:24]([O:25][CH3:26])=[C:23]([CH2:15][C@H:9]([NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH2:10][C:11]([O:13][CH3:14])=[O:12])[CH:22]=1

Komponenten

5

Edukt 3

HCID 80271Tri-o-tolylphosphineHCID 11382308Methyl (R)-3-((tert-butoxycarbonyl)amino)-4-iodobutanoateHCID 220545963-Iodo-4-methoxyaniline

Produkt 1

HCID 118276697Methyl (3S)-4-(5-amino-2-methoxy-phenyl)-3-(tert-butoxycarbonylamino)-butanoateAusbeute 66 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23994ZincKatalysator

Versuchsvorschrift

Following the General Procedure of Description 15 (Part A), the zinc insertion product of (5c) was used in situ to cross couple with commercial 3-iodo-4-methoxy-aniline (249 mg, 1.0 mmol) in the presence of tris(benzylideneacetone)dipalladium (Pd2(dba)3) (23 mg, 0.025 mmol, 2.5 mol-%) and tris(o-tolyl)phosphine (P(o-tol)3) (30 mg, 0.10 mmol, 10 mol-%) in anhydrous degassed DMF (3 mL). Filtration, aqueous work-up, and purification by silica gel column chromatography with ethyl acetate (EtOAc)/hexane and dichloromethane(DCM)/EtOAc mixtures (EtOAc/hexane=1:1, v/v→DCM/EtOAc=1:1, v/v) furnished ˜280 mg (66% yield; ˜80% purity by AUC) of the title compound (7a) as a yellow viscous oil. Rf˜0.23 (EtOAc/hexane=1:1, v/v). 1H NMR (300 MHz, CDCl3): δ 6.90 (br s, 1H), 6.78 (br. d, J=8.1 Hz, 1H), 6.70 (d, J=8.7 Hz, 1H), 5.28 (br. d, J=8.1 Hz, 1H), 4.40-4.10 (m, 1H), 3.37 (s, 3H), 2.90-2.80 (br. m, 1H), 2.75 (dd, J=12.6, 6.3 Hz, 1H), 2.50 (d, J=5.1 Hz, 2H), 1.35 (s, 9H) ppm. LC/MS: Rt=0.908 min; ESI (pos.) m/z=339.15 (M+H+)+, 677.40 (2M+H+)+, 699.35 (2M+Na+)+.

Aufarbeitung

  1. customin anhydrous degassed DMF (3 mL)
  2. filtrationFiltration, aqueous work-up, and purification by silica gel column chromatography with ethyl acetate (EtOAc)/hexane and dichloromethane(DCM)/EtOAc

Quellen und Nachweise

ORD-Eintrag
ord-be59ff4b0920471b808edd23c681699d
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09394237B2

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