[CH3:1][C:2]([O:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15]([C@@H:17]2[CH2:21][C@H:20]([N:22]3[CH2:27][CH2:26][N:25]([S:28]([CH3:31])(=[O:30])=[O:29])[CH2:24][CH2:23]3)[CH2:19][N:18]2C(OCC2C=CC=CC=2)=O)=[O:16])=[CH:10][CH:9]=1)=[O:7])([CH3:4])[CH3:3]>C(O)C.[Pd]>[CH3:31][S:28]([N:25]1[CH2:26][CH2:27][N:22]([C@@H:20]2[CH2:19][NH:18][C@H:17]([C:15]([NH:14][C:11]3[CH:12]=[CH:13][C:8]([C:6]([O:5][C:2]([CH3:1])([CH3:4])[CH3:3])=[O:7])=[CH:9][CH:10]=3)=[O:16])[CH2:21]2)[CH2:23][CH2:24]1)(=[O:30])=[O:29]To a solution of the compound prepared in Example 5 (2.1 g, 7.4 mmol) in ethanol (100 mL) was added Pd/C (0.40 g, 20% by wt). The reaction was stirred under an atmosphere of hydrogen (50 psi) at room temperature for 6 h. The reaction mixture was filtered through diatomaceous earth and concentrated to give the title compound (1.10 g, 69%) as a white solid.
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