Diisopropylethylamine → HCID 90017038, Verbindung

HRID 1055003Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1055003
[CH3:1][N:2]1[C:6]([CH2:7][CH2:8][C:9]([OH:11])=O)=[N:5][C:4]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)=[N:3]1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(CC)C(C)C)(C)C.[CH2:50]([C:52]1[C:53]([NH:59][NH2:60])=[N:54][C:55]([CH3:58])=[N:56][CH:57]=1)[CH3:51]>CN(C)C=O>[CH2:50]([C:52]1[C:53]([NH:59][NH:60][C:9](=[O:11])[CH2:8][CH2:7][C:6]2[N:2]([CH3:1])[N:3]=[C:4]([N:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)[N:5]=2)=[N:54][C:55]([CH3:58])=[N:56][CH:57]=1)[CH3:51]

Komponenten

6

Edukt 4

HCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 83891736HCID 83891736, VerbindungHCID 90016952HCID 90016952, Verbindung

Produkt 1

HCID 90017038HCID 90017038, VerbindungAusbeute 31,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

3-(1-Methyl-3-(pyrrolidin-1-yl)-1H-1,2,4-triazol-5-yl)propanoic acid (140 mg, 0.624 mmol), HATU (712 mg, 1.87 mmol) and N,N-diisopropylethylamine (600 μl, 3.53 mmol) were dissolved in dimethylformamide (18 mL). The mixture was stirred for 20 minutes. 5-Ethyl-4-hydrazinyl-2-methylpyrimidine (99 mg, 0.655 mmol) was added and the reaction mixture was allowed to stir at room temperature overnight. The mixture was concentrated to an oil. Preparative HPLC afforded the desired product (71 mg, 31%) as a yellow gum. MS: m/z=359.23 (M+H+)

Aufarbeitung

  1. stirringto stir at room temperature overnight
  2. concentrationThe mixture was concentrated to an oil

Quellen und Nachweise

ORD-Eintrag
ord-d44a75693d2d43e09f9ea0eda6a18c1d
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09394311B2

Notizen zur Reaktion

Wird geladen…