Water → HCID 90037382, Verbindung

HRID 1055412Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1055412
[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:11]#[N:12].F[C:14]1[CH:21]=[CH:20][CH:19]=[CH:18][C:15]=1[C:16]#[N:17].C([O-])([O-])=O.[Cs+].[Cs+].O>CN(C=O)C>[C:16]([C:15]1[CH:18]=[CH:19][CH:20]=[CH:21][C:14]=1[N:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[C:2]([CH3:1])=[C:3]1[C:11]#[N:12])#[N:17]

Komponenten

6

Edukt 4

HCID 962WaterHCID 10796Cesium carbonateHCID 678552-FluorobenzonitrileHCID 5933713-Methyl-1H-indole-2-carbonitrile

Produkt 1

HCID 90037382HCID 90037382, VerbindungAusbeute 94,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A mixture of 3-methyl-1H-indole-2-carbonitrile (500 mg, 3.2 mmol), 2-fluorobenzonitrile (388 mg, 3.2 mmol) and Cs2CO3 (1.05 g, 3.2 mmol) in DMF (10 mL) was heated at 60° C. overnight. The mixture was poured into H2O and a precipitate formed. The solid was collected by filtration, washed with H2O and hexane, and dried under vacuum to give 1-(2-cyanophenyl)-3-methyl-1H-indole-2-carbonitrile (780 mg, 94.6%) as an off white solid that was used without purification.

Aufarbeitung

  1. customa precipitate formed
  2. filtrationThe solid was collected by filtration
  3. washwashed with H2O and hexane
  4. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-64051bb5bd894dc69ab7f1c804b95350
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09394263B2

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