Pyruvic Acid → HCID 178432270, Verbindung

HRID 1056243

Reaktionsgleichung

Reaktionsgleichung von HRID 1056243
[NH2:1][C:2]1[C:3]([Cl:9])=[N:4][CH:5]=[CH:6][C:7]=1[NH2:8].[C:10](O)(=[O:14])[C:11]([CH3:13])=O>CO>[Cl:9][C:3]1[C:2]2=[N:1][C:10]([OH:14])=[C:11]([CH3:13])[N:8]=[C:7]2[CH:6]=[CH:5][N:4]=1

Komponenten

4

Edukt 2

HCID 1060Pyruvic AcidHCID 2857362-Chloropyridine-3,4-diamine

Produkt 1

HCID 178432270HCID 178432270, VerbindungAusbeute 65,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

A mixture of 3,4-diamino-2-chloropyridine (2.1 g, 14.63 mmol) (Sigma Aldich) and pyruvic acid (1.22 mL, 17.55 mmol) (Acros, New Jersey) in MeOH (40 mL) in a sealed glass tube was heated at 50° C. for 2 h. The mixture was cooled to RT and the solvent was removed in vacuo. The residue was triturated with ether and the suspension was filtered to give 1.88 g of crude product. MS (ESI, pos. ion) m/z: 196.1 (M+1).

Aufarbeitung

  1. temperatureThe mixture was cooled to RT
  2. customthe solvent was removed in vacuo
  3. customThe residue was triturated with ether
  4. filtrationthe suspension was filtered

Quellen und Nachweise

ORD-Eintrag
ord-5c3cc1e123fc447d8c33780bcb59abdc
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09394297B2

Verknüpfte Notizen

Wird geladen…