(4-Chlorophenyl)(phenyl)methanamine → (4-Chlorophenyl)(phenyl)methanamine, (S)-

HRID 1056469

Reaktionsgleichung

Reaktionsgleichung von HRID 1056469
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH:6]([NH2:13])[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.C(O)(=O)[C@H]([C@@H](C(O)=O)O)O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C@@H:6]([NH2:13])[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:14][CH:15]=1

Komponenten

3

Edukt 2

HCID 409810(4-Chlorophenyl)(phenyl)methanamineHCID 439655D-Tartaric acid

Produkt 1

HCID 736032(4-Chlorophenyl)(phenyl)methanamine, (S)-

Versuchsvorschrift

The racemic 4-chlorobenzhydrylamine was treated with D-tartaric acid, and then sequentially recrystallized ten times from water (as described by Clemo, et al., J. Chem. Soc., (1939), 1958-1960) to provide (S)-4-chlorobenzhydrylamine of high optical purity (ee>98%, according to chiral HPLC).

Aufarbeitung

  1. customsequentially recrystallized ten times from water (as described by Clemo, et al., J. Chem. Soc., (1939), 1958-1960)

Quellen und Nachweise

ORD-Eintrag
ord-5c7d83a10736459f804e1b03d1c4e82d
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09399032B2

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