Dichloromethane → Chloromethyl 2-{[(tert-butoxy)carbonyl]amino}acetate

HRID 1056577Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1056577
[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].C([O-])(O)=O.[Na+].[CH2:18](Cl)[Cl:19]>O>[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]([O:12][CH2:18][Cl:19])=[O:11])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Komponenten

5

Edukt 3

HCID 6344Dichloromethane2×HCID 78288N-(tert-butoxycarbonyl)glycineHCID 516892Sodium Bicarbonate

Produkt 1

HCID 12968718Chloromethyl 2-{[(tert-butoxy)carbonyl]amino}acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

The title compound was prepared according to the procedure as described in Example 17 Step 1 using 2-((tert-butoxycarbonyl)amino)acetic acid (1 g, 5.7 mmol) in DCM (25 mL) and H2O (25 mL), NaHCO3 (1.92 g, 22.8 mmol), TBAHSO4 (194 mg, 0.57 mmol) and a solution of chloromethyl sulfochloridate (693 mL, 6.8 mmol) in DCM (5 mL). The title compound was obtained as colorless oil (911 mg, 71.3%).

Aufarbeitung

  1. customThe title compound was prepared

Quellen und Nachweise

ORD-Eintrag
ord-0088c5696bdd4a198c42c89ac1a3e887
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09399639B2

Notizen zur Reaktion

Wird geladen…