2-Chloropyridine → 2-(N-Methyl-N-(2-pyridyl)amino)ethanol

HRID 1058088Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1058088
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:8][NH:9][CH2:10][CH2:11][OH:12]>>[CH3:8][N:9]([CH2:10][CH2:11][OH:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1

Komponenten

3

Edukt 2

HCID 79772-ChloropyridineHCID 80162-(Methylamino)ethanol

Produkt 1

HCID 7374202-(N-Methyl-N-(2-pyridyl)amino)ethanol

Versuchsvorschrift

The reaction of 2-chloropyridine with 2-(N-methyl amino)ethanol provides 2-(N-methyl-N-(2-pyridyl)amino)ethanol (II), which on coupling reaction with 4-fluorobenzaldehyde (III) in an aprotic polar solvent with an alkali metal hydroxide or an alkali metal alkoxide as base yields 4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzaldehyde (IV) with an 88% yield (Reaction I).

Quellen und Nachweise

ORD-Eintrag
ord-e58b72df1612415e90e00bb4f473b1d1
Quelldatensatz
uspto-grants-2003_02
Patentnummer
US06515132B2

Notizen zur Reaktion

Wird geladen…