Ammonia → 6-Amino-2-fluoronicotinamide

HRID 1059628Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1059628
[F:1][C:2]1[N:10]=[C:9](F)[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[NH3:12].O>C(N)=O>[NH2:12][C:9]1[CH:8]=[CH:7][C:3]([C:4]([NH2:6])=[O:5])=[C:2]([F:1])[N:10]=1

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 962WaterHCID 105830482,6-Difluoropyridine-3-carboxamide

Produkt 1

HCID 105348946-Amino-2-fluoronicotinamideAusbeute 31 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 713FormamideLösungsmittel

Versuchsvorschrift

A solution of 2,6-difluoronicotinamide (4.68 g, 0.029 mmol) in dry formamide (30 mL) is saturated with ammonia and allowed to stand at room temperature for 24 h. Water (50 mL) is added and the resultant precipitate is filtered off and washed well with water, to give 6-amino-2-fluoronicotinamide (1.41 g, 31%) mp 236-237° C. 1H NMR (DMSO) δ 7.89 (1H, dd, J=10.4, 8.4 Hz), 7.31, 7.16 (1H, 1H, 2 brs,), 6.93 (2H, brs), 6.36 (1H, dd, J=8.4, 2.4 Hz).

Aufarbeitung

  1. filtrationthe resultant precipitate is filtered off
  2. washwashed well with water

Quellen und Nachweise

ORD-Eintrag
ord-8cc5c147cf8d4fbdbaf21d64a3c746ef
Quelldatensatz
uspto-grants-2003_02
Patentnummer
US06521620B1

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