Water → N-(3-(4-methylpyridin-2-yl)phenyl)-N'-benzoylthiourea

HRID 1059986Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1059986
[N-:1]=[C:2]=[S:3].[NH4+].[C:5](Cl)(=[O:12])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[CH3:14][C:15]1[CH:20]=[CH:19][N:18]=[C:17]([C:21]2[CH:22]=[C:23]([CH:25]=[CH:26][CH:27]=2)[NH2:24])[CH:16]=1.O>CC(C)=O>[CH3:14][C:15]1[CH:20]=[CH:19][N:18]=[C:17]([C:21]2[CH:22]=[C:23]([NH:24][C:2]([NH:1][C:5](=[O:12])[C:6]3[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=3)=[S:3])[CH:25]=[CH:26][CH:27]=2)[CH:16]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 7412Benzoyl chlorideHCID 186676162-(3-Aminophenyl)-4-methylpyridineHCID 178514171HCID 178514171, Verbindung

Produkt 1

HCID 18667641N-(3-(4-methylpyridin-2-yl)phenyl)-N'-benzoylthiourea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel2×

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

To a stirred solution of ammonium isothiocyanate (142 mg) in acetone (3 ml) was added benzoyl chloride (0.199 ml) at 50° C., and the mixture was stirred at 50° C. for 10 minutes. To the resultant suspension was added a solution of 3-(4-methylpyridin-2-yl)aniline (300 mg) in acetone (6 ml) dropwise, and the mixture was stirred at 60° C. for 2 hours. Water was added to the reaction mixture, and the precipitate was collected by filtration and dried to give N-(3-(4-methylpyridin-2-yl)phenyl)-N′-benzoylthiourea (557 mg).

Aufarbeitung

  1. stirringthe mixture was stirred at 60° C. for 2 hours
  2. filtrationthe precipitate was collected by filtration
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-64c4e228b5c74060b212562539a93f22
Quelldatensatz
uspto-grants-2003_02
Patentnummer
US06521643B1

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