Dimethyl Sulfoxide → 2-(3-{[2,2-Difluoro-2-(4-fluoronaphthyl)ethyl]amino]-6-chloro-2-fluorophenyl)ethanal

To a solution of DMSO (470 mg, 6.0 mmol), DIEA (823 μL, 4.74 mmol) and 2-(3-{[2,2-difluoro-2-(4-fluoronaphthyl)ethyl]amino}-6-chloro-2-fluorophenyl)ethanol (723 mg, 1.82 mmol), as prepared in the preceding step, in DCM (55 mL) in an ice-bath was added sulfur trioxide pyridine complex (754 mg, 4.74 mmol). After stirring for 3.5 hours the reaction mixture was diluted with DCM (110 mL). The organic layer was separated, and the aqueous layer extracted with DCM (100 mL). The organic layers were combined, washed with 10% citric acid (3 times), H2O, and brine, dried over Na2SO4, and concentrated to give the title compound (722 mg, quantitative yield) as an orange oil. 1H-NMR (400 MHz, CDCl3) δ 9.69 (d, J=1.1 Hz, 1H), 8.22-8.18 (m, 2H), 7.67 -7.60 (m, 3H), 7.14 (t, J=9.2 Hz, 1H), 6.94 (d, J=8.8 Hz, 1H), 6.49 (t, J=8.7 Hz, 1H), 4.20 (bs, 1H), 4.00 (dt, J=13.3, 6.7 Hz, 2H), 3.83 (s, 2H).

1. additionwas added sulfur trioxide pyridine complex (754 mg, 4.74 mmol)
2. customThe organic layer was separated
3. extractionthe aqueous layer extracted with DCM (100 mL)
4. washwashed with 10% citric acid (3 times), H2O, and brine
5. dry with materialdried over Na2SO4
6. concentrationconcentrated

ORD-Eintrag

ord-e5e2537867a941468d1288f47a19b78a

Quelldatensatz

uspto-grants-2003_02

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06521663B2