N-Hydroxyphthalimide → 2-(1-Hydroxymethyl-cyclopropylmethoxy)-isoindole-1,3-dione

HRID 1062264

Reaktionsgleichung

[OH:1][CH2:2][C:3]1([CH2:6][OH:7])[CH2:5][CH2:4]1.O[N:9]1[C:13](=[O:14])[C:12]2=[CH:15][CH:16]=[CH:17][CH:18]=[C:11]2[C:10]1=[O:19].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N(C(OCC)=O)=NC(OCC)=O>O1CCCC1>[OH:1][CH2:2][C:3]1([CH2:6][O:7][N:9]2[C:13](=[O:14])[C:12]3[C:11](=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:10]2=[O:19])[CH2:5][CH2:4]1

Komponenten

Reaktionsbedingungen

Temperatur: 0 °C

Versuchsvorschrift

(1-Hydroxymethyl-cyclopropyl)-methanol (4.08 g, 0.04 mol), N-hydroxyphthalimide (6.53 g, 0.04 mol) and triphenylphosphine (10.50 g, 0.04 mol) were combined in anhydrous tetrahydrofuran (100 mL) and stirred at 0° C. for 1.5 hours. Diethyl azodicarboxylate (6.97 g, 0.04 mol) was added at 0° C. and the reaction mixture was stirred at room temperature overnight. Repeated concentration of the reaction mixture from chloroform and filtration of the resulting precipitate (triphenylphosphine oxide) afforded the crude product which was further purified by silica gel chromatography. Elution with hexane/ethyl acetate (3:2) provided 2-(1-Hydroxymethyl-cyclopropylmethoxy)-isoindole-1,3-dione (5.63 g, 57% yield) as a white solid: 1H NMR (400 MHz; CDCl3) δ 7.82-7.85 (2H, m), 7.74-7.78 (2H, m), 4.19 (2H, s), 3.72 (2H, s), 0.63 (4H, s)

Aufarbeitung

stirringthe reaction mixture was stirred at room temperature overnight
filtrationfrom chloroform and filtration of the resulting precipitate (triphenylphosphine oxide)
customafforded the crude product which
customwas further purified by silica gel chromatography
washElution with hexane/ethyl acetate (3:2)

Quellen und Nachweise

ORD-Eintrag: ord-36bac526e7db48d1859f8241c82ecd95
Quelldatensatz: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06960614B2

Verknüpfte Notizen

Wird geladen…