Water → HCID 11617092, Verbindung

HRID 1062645

Reaktionsgleichung

Reaktionsgleichung von HRID 1062645
[C:1]([O:5][C:6]([NH:8][C:9]1[CH:14]=[C:13]([CH3:15])[CH:12]=[CH:11][N:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:16]([Li])[CH2:17][CH2:18][CH3:19].[CH3:21][CH2:22][CH2:23]CCC.[OH2:27].C([O:31][CH:32](C)C)(C)C>O1CCCC1>[C:1]([O:5][C:6]([NH:8][C:9]1[CH:14]=[C:13]([CH2:15][C:16]([C:17]2[CH:21]=[CH:22][C:23]([O:31][CH3:32])=[CH:19][CH:18]=2)=[O:27])[CH:12]=[CH:11][N:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Komponenten

6

Edukt 4

HCID 962WaterHCID 7914Diisopropyl EtherHCID 11063648tert-butyl N-(4-methylpyridin-2-yl)carbamateHCID 178418244HCID 178418244, Verbindung

Produkt 1

HCID 11617092HCID 11617092, VerbindungAusbeute 69 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Reaktionsbedingungen

Temperatur
-78 °C

Versuchsvorschrift

A solution of 2-tert-butoxycarbonylamino-4-methylpyridine (20 g, 97 mmol) in anhydrous tetrahydrofuran (300 mL) was cooled to −78° C. and 1.6 M n-butyllithium/hexane solution (140 mL, 0.23 mol) was added dropwise with stirring. After completion of the dropwise addition, the mixture was stirred at room temperature for 30 min and cooled to −78° C. A solution of N-(4-methoxybenzoyl)propyleneimine (25 g, 0.13 mol) in anhydrous tetrahydrofuran (50 mL) was added dropwise. After completion of the dropwise addition, the mixture was stirred at room temperature for 2 h. To the reaction mixture were added water (100 mL) and isopropyl ether (300 mL), and the obtained crude crystals were collected by filtration. The crude crystals were recrystallized from tetrahydrofuran-hexane to give the title compound (23 g, yield 69%).

Aufarbeitung

  1. additionAfter completion of the dropwise addition
  2. stirringthe mixture was stirred at room temperature for 30 min
  3. additionAfter completion of the dropwise addition
  4. stirringthe mixture was stirred at room temperature for 2 h
  5. customthe obtained crude crystals
  6. filtrationwere collected by filtration
  7. customThe crude crystals were recrystallized from tetrahydrofuran-hexane

Quellen und Nachweise

ORD-Eintrag
ord-2e1c2879308049c4b0676845538ff3f4
Quelldatensatz
uspto-grants-2005_11
Patentnummer
US06962933B1

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