Sodium Hydroxide → 3-(Pyridin-4-yl)butanoic acid
Reaktionsgleichung
[OH-].[Na+].[CH3:3][CH:4]([C:11]1[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=1)[CH2:5][C:6]([O:8]CC)=[O:7]>CO.O>[CH3:3][CH:4]([C:11]1[CH:12]=[CH:13][N:14]=[CH:15][CH:16]=1)[CH2:5][C:6]([OH:8])=[O:7]Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
Sodium hydroxide (0.19 g, 4.8 mmol) was added to a solution of ethyl 3-methyl-3-pyridin-4-ylpropanoate (Method 8; 0.501 g, 2.6 mmol) in MeOH (10 ml) and water (5 ml). The mixture was stirred at room temperature for 18 hours. The solvent was removed in vacuo and the residue shaken with 1 M hydrochloric acid (4.8 ml). The solvent was removed in vacuo to leave a colourless solid. M/z 164 (M−H)−.
Aufarbeitung
- customThe solvent was removed in vacuo
- stirringthe residue shaken with 1 M hydrochloric acid (4.8 ml)
- customThe solvent was removed in vacuo
- customto leave a colourless solid
Quellen und Nachweise
- ORD-Eintrag
- ord-95347b088f054b708122c2fce44f1fa6
- Quelldatensatz
- uspto-grants-2005_11
- Patentnummer
- US06967216B2
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