Boron trifluoride → 1-tert-Butyl-4-(3-chloro-2-methylpropyl)benzene

HRID 1065178

Reaktionsgleichung

Reaktionsgleichung von HRID 1065178
B(F)(F)F.[CH3:5][CH:6]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:7][Cl:8].[C:16](Cl)([CH3:19])([CH3:18])[CH3:17]>O>[CH3:5][CH:6]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:7][Cl:8].[CH3:5][CH:6]([CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]([CH3:19])([CH3:18])[CH3:17])=[CH:12][CH:11]=1)[CH2:7][Cl:8]

Komponenten

6

Edukt 3

HCID 6356Boron trifluoride2×HCID 10486tert-BUTYL CHLORIDEHCID 13510156(3-Chloro-2-methylpropyl)benzene

Produkt 2

HCID 132518171-tert-Butyl-4-(3-chloro-2-methylpropyl)benzeneHCID 13510156(3-Chloro-2-methylpropyl)benzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

BF3 is passed for 30 minutes into a mixture of 84 parts by weight of 2-methyl-3-phenyl-propyl chloride and 50 ml of BF3 ·2H2O at room temperature. 56 parts by weight of tert.-butyl chloride are then added dropwise at room temperature. The mixture is refluxed for 4 hours and is then allowed to cool; the crude product is introduced into water and extracted with chloroform. The organic phase is separated off, washed with water, dried over Na2CO3 and distilled. 30 parts by weight of 2-methyl-3-phenyl-propyl chloride, boiling point 105° C./16 mm Hg, and 45 parts by weight of 2-methyl-3-(p-tert.-butylphenyl)-propyl chloride, boiling point 80° C.-81° C./0.02 mm Hg, are obtained.

Aufarbeitung

  1. customat room temperature
  2. temperatureThe mixture is refluxed for 4 hours
  3. temperatureto cool
  4. extractionextracted with chloroform
  5. customThe organic phase is separated off
  6. washwashed with water
  7. dry with materialdried over Na2CO3
  8. distillationdistilled

Quellen und Nachweise

ORD-Eintrag
ord-62ed638def68417c87c569adbce2f41d
Quelldatensatz
uspto-grants-1982_05
Patentnummer
US04328380

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