Hydrochloric Acid → 5-Chlorouracil

Reaktionsgleichung

Cl.[Cl:2][C:3]1(C(OC)=O)[CH:8](O)[NH:7][C:6](=[O:10])[NH:5][C:4]1=[O:11]>>[Cl:2][C:3]1[C:4](=[O:11])[NH:5][C:6](=[O:10])[NH:7][CH:8]=1

Komponenten

Edukt 2

HCID 313Hydrochloric Acid

HCID 12890662Methyl 5-chloro-6-hydroxy-1,2,3,4,5,6-hexahydro-2,4-dioxopyrimidine-5-carboxylate

Produkt 1

HCID 157585-Chlorouracil

Versuchsvorschrift

In 15 ml. of concentrated hydrochloric acid, 345 mg. of methyl 5-chloro-6-hydroxy-1,2,3,4,5,6-hexahydro-2,4-dioxopyrimidine-5-carboxylate is heated under reflux for 15 hours. The reaction mixture is cooled with ice, whereupon 92 mg. of 5-chlorouracil is obtained as colorless prisms.

Aufarbeitung

temperatureunder reflux for 15 hours
temperatureThe reaction mixture is cooled with ice, whereupon 92 mg

Quellen und Nachweise

ORD-Eintrag: ord-38903b307ce349258b3a3861a9e96bb1
Quelldatensatz: uspto-grants-1982_05
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04329460

Notizen zur Reaktion

Wird geladen…