Phenyl isocyanate → N-(4-pyridazinyl)-N'-phenylurea

HRID 1065941

Reaktionsgleichung

Reaktionsgleichung von HRID 1065941
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[N:4][CH:3]=1.[C:8]1([N:14]=[C:15]=[O:16])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>CC(C)=O>[N:5]1[CH:6]=[CH:7][C:2]([NH:1][C:15]([NH:14][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:16])=[CH:3][N:4]=1

Komponenten

4

Edukt 2

HCID 7672Phenyl isocyanateHCID 2984924-Aminopyridazine

Produkt 1

HCID 12893792N-(4-pyridazinyl)-N'-phenylurea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

200 mg. of 4-aminopyridazine was suspended in 50 ml. of acetone. To the resulting suspension, 1.2 times the amount of phenyl isocyanate theoretically calculated was added and the mixture then reacted at room temperature overnight. The crystals formed were taken out by filtration. By recrystallization from an excess of methanol, N-(4-pyridazinyl)-N'-phenylurea was obtained (yield, greater than 80%); melting point higher than 250° C.

Aufarbeitung

  1. customthe mixture then reacted at room temperature overnight
  2. customThe crystals formed
  3. filtrationwere taken out by filtration
  4. customBy recrystallization from an excess of methanol

Quellen und Nachweise

ORD-Eintrag
ord-b643778aea364656bc2dd9c46168b1ef
Quelldatensatz
uspto-grants-1982_05
Patentnummer
US04331807

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