Hydrochloric Acid → HCID 20573874, Verbindung

HRID 1065961

Reaktionsgleichung

Reaktionsgleichung von HRID 1065961
C[O:2][C:3]1[CH:10]=[C:9](OC)[C:6]([CH:7]=O)=[C:5]([OH:13])[CH:4]=1.[CH3:14][C:15]([C:17]1[CH:22]=[CH:21][C:20]([O:23]C)=[CH:19][CH:18]=1)=[O:16].[ClH:25]>CCOCC>[CH:18]1[C:17]([C:15]2[CH:14]=[CH:7][C:6]3[C:5]([OH:13])=[CH:4][C:3]([OH:2])=[CH:10][C:9]=3[O+:16]=2)=[CH:22][CH:21]=[C:20]([OH:23])[CH:19]=1.[Cl-:25].[Cl-:25]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 74764'-MethoxyacetophenoneHCID 697254,6-Dimethoxysalicylaldehyde

Produkt 1

HCID 20573874HCID 20573874, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

One method consists, for example, in preparing, in a first step, trimethylapigenidin by condensation of commercially available 4,6-dimethoxy-2-hydroxybenzaldehyde with commercially available 4-methoxyacetophenone at 0° C. in anhydrous ether medium, and saturation with anhydrous HCl in order to obtain, after filtration, an orange-red precipitate of trimethylapigenidin. In a second step, in hydrolysing the trimethylapigenidin obtained in the preceding step to apigenidin chloride, the reaction being carried out in an HI and phenol and AgCl medium in solution in methanol. Such a method of synthesis is described by R. Robinson and A. Robertson in J., Chem., Soc. 1951-(1926) and 2196-(1927).

Aufarbeitung

  1. customto obtain
  2. filtrationafter filtration

Quellen und Nachweise

ORD-Eintrag
ord-950eaab79849496da2cb9d7fe7039fdb
Quelldatensatz
uspto-grants-2001_06
Patentnummer
US06241785B1

Verknüpfte Notizen

Wird geladen…