Water → N-(n-pentanesulfonyl)-3-amino-4-nitrobenzamide

HRID 1066338Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1066338
[CH2:1]([S:6]([NH:9][C:10](=[O:24])[C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[C:13]([NH:20]C(=O)C)[CH:12]=1)(=[O:8])=[O:7])[CH2:2][CH2:3][CH2:4][CH3:5].O.[OH-].[Na+]>C(O)C>[CH2:1]([S:6]([NH:9][C:10](=[O:24])[C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[C:13]([NH2:20])[CH:12]=1)(=[O:7])=[O:8])[CH2:2][CH2:3][CH2:4][CH3:5]

Komponenten

5

Edukt 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 21198585N-(n-pentanesulfonyl)-3-(acetylamino)-4-nitrobenzamide

Produkt 1

HCID 21198604N-(n-pentanesulfonyl)-3-amino-4-nitrobenzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
47.5 °C

Versuchsvorschrift

The above partially purified product of N-(n-pentanesulfonyl)-3-(acetylamino)-4-nitrobenzamide was mixed with 300 ml of water and 500 ml of ethanol. Two-hundred grams of a 10%-sodium hydroxide aqueous solution were added thereto, and the mixture was stirred at 45 to 50° C. for 6 hours. The solvent (approx. 300 ml) was evaporated under reduced pressure. The resulting residue was neutralized with 10% hydrochloric acid aqueous solution and adjusted to pH 2 with diluted hydrochloric acid. The precipitated crystals were collected by filtration and dried to give 85.0 g of yellow crystals of N-(n-pentanesulfonyl)-3-amino-4-nitrobenzamide.

Aufarbeitung

  1. customThe solvent (approx. 300 ml) was evaporated under reduced pressure
  2. filtrationThe precipitated crystals were collected by filtration
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-a720b1cead6a4e5ebdec248b4897d014
Quelldatensatz
uspto-grants-2001_06
Patentnummer
US06242474B1

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