Reaktionsgleichung
[CH3:1][O:2][C:3]1[C:8]([O:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16][CH3:17])=[C:7]([NH:18][S:19]([C:22]2[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][N:23]=2)(=[O:21])=[O:20])[N:6]=[C:5]([C:29]2[CH:34]=[CH:33][N:32]=[C:31]([C:35]([OH:37])=[O:36])[CH:30]=2)[N:4]=1.[C:38](=[O:50])([O:46][CH:47](Cl)[CH3:48])[O:39][CH:40]1[CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]1>>[CH:40]1([O:39][C:38]([O:46][CH:47]([O:36][C:35]([C:31]2[CH:30]=[C:29]([C:5]3[N:4]=[C:3]([O:2][CH3:1])[C:8]([O:9][C:10]4[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=4[O:16][CH3:17])=[C:7]([NH:18][S:19]([C:22]4[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][N:23]=4)(=[O:21])=[O:20])[N:6]=3)[CH:34]=[CH:33][N:32]=2)=[O:37])[CH3:48])=[O:50])[CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]1Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
In analogy to example 77, from 4-[4-methoxy-5-(2-methoxy-phenoxy)-6-(5-methyl-pyridine-2-sulfonylamino)-pyrimidin-2-yl]-pyridine-2-carboxylic acid, product of example 21, and cyclohexyl 1-chlorethyl carbonate (synthesis described by A. Riondel et al., Tetrahedron, 1988, Vol. 44, 1619) there was obtained 4-[4-methoxy-5-(2-methoxy-phenoxy)-6-(5-methyl-pyridine-2-sulfonylamino)-pyrimidin-2-yl]-pyridine-2-carboxylic acid 1-cyclohexyloxycarbonyloxy-ethyl ester as a white solid. ISN mass spectrum, m/e 692.1 (M−1 calculated for C33H35N5O10S: 692).
Quellen und Nachweise
- ORD-Eintrag
- ord-a0bf915339e2443c824931d35bba15b4
- Quelldatensatz
- uspto-grants-2001_06
- Patentnummer
- US06242601B1
Verknüpfte Notizen
Wird geladen…