Hydrochloric Acid → HCID 314717, Verbindung

Under a nitrogen atmosphere 4-methylpiperidine (0.109 ml, 0.09 g, 0.92 mmol), dissolved in 2.0 ml of ethyl acetate, was added to a round bottom flask which was then placed in an ice bath. Concentrated hydrochloric acid (0.084 ml) was then added and the reaction mixture was removed from the ice bath. To the reaction mixture were added formaldehyde (0.304 g, 1.01 mmol), sodium acetate (0.113 g, 1.38 mmol), and 1-methyl-2-(4-chlorophenoxymethyl)-1H-indole (0.250 g, 0.92 mmol). The resulting mixture was then heated to reflux and maintained at this temperature overnight. The progress of the reaction was monitored by thin layer chromatography.

1. additionwas added to a round bottom flask which
2. customwas then placed in an ice bath
3. customthe reaction mixture was removed from the ice bath
4. temperatureThe resulting mixture was then heated
5. temperatureto reflux
6. temperaturemaintained at this temperature overnight

ORD-Eintrag

ord-c54c517730a2470e9ea808fc56c5b5cc

Quelldatensatz

uspto-grants-2001_06

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06245761B1