Tert-Butyl nitrite → HCID 23445659, Verbindung

HRID 1067358

Reaktionsgleichung

Reaktionsgleichung von HRID 1067358
[Br:1][C:2]1[CH:8]=[C:7]([CH2:9][CH3:10])[C:5]([NH2:6])=[C:4]([CH2:11][CH3:12])[CH:3]=1.[F:13][B-:14]([F:17])([F:16])[F:15].[H+].[N:19](OC(C)(C)C)=O>C(O)C>[F:13][B-:14]([F:17])([F:16])[F:15].[Br:1][C:2]1[CH:8]=[C:7]([CH2:9][CH3:10])[C:5]([N+:6]#[N:19])=[C:4]([CH2:11][CH3:12])[CH:3]=1

Komponenten

5

Edukt 3

HCID 10906Tert-Butyl nitriteHCID 28118Tetrafluoroboric acidHCID 6114524-Bromo-2,6-diethylaniline

Produkt 1

HCID 23445659HCID 23445659, VerbindungAusbeute 66 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

At 0° C., to a stirred solution of commercial 4-bromo-2,6-diethylaniline (10.0 g, 43.9 mmol) in absolute ethanol (219 mL) was added 48% aq. tetrafluoroboric acid (17.2 mL), followed by tert-butyl nitrite (5.7 mL, 48.0 mmol). After 0.5 h, the reaction was poured into ice cold ether (877 mL). The resulting precipitate was washed with cold ether and dried to give 9.39 g (66%) of the title compound. 1H NMR: consistent.

Aufarbeitung

  1. washThe resulting precipitate was washed with cold ether
  2. customdried

Quellen und Nachweise

ORD-Eintrag
ord-b8e222e004b5461f856955c16ca5661e
Quelldatensatz
uspto-grants-2001_06
Patentnummer
US06248764B1

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