Triethylamine → HCID 614880, Verbindung

HRID 1069525Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1069525
Cl[C:2]1[C:11]2[C:6](=[C:7]([O:12][CH3:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:14]([F:17])([F:16])[F:15])[CH:3]=1.CCN(CC)CC>CCO.[Pd]>[CH3:13][O:12][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:6]=1[N:5]=[C:4]([C:14]([F:17])([F:15])[F:16])[CH:3]=[CH:2]2

Komponenten

5

Edukt 2

HCID 8471TriethylamineHCID 6215244-Chloro-8-methoxy-2-(trifluoromethyl)quinoline

Produkt 1

HCID 614880HCID 614880, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 4-chloro-8-methoxy-2-trifluoromethylquinoline (0.57 g) in 5 mL absolute EtOH is added 10% Pd/C (125 mg) and NEt3 (0.3 mL). The reaction is hydrogenated under atmospheric pressure for 0.75 h. The reaction is then filtered over Celite and the filtrate is evaporated. The residue is taken up in Et2O and the triethylamine hydrochloride salt is filtered. The desired product is obtained as a light yellow solid by evaporation of the Et2O filtrate (0.38 g).

Aufarbeitung

  1. filtrationThe reaction is then filtered over Celite
  2. customthe filtrate is evaporated
  3. filtrationthe triethylamine hydrochloride salt is filtered

Quellen und Nachweise

ORD-Eintrag
ord-a266e31e89594482909545a84f3f93ae
Quelldatensatz
uspto-grants-2001_06
Patentnummer
US06252080B1

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