N-BOC-ethylenediamine → HCID 22396192, Verbindung

HRID 1070489Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1070489
[Cl:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][C:15]=1[Cl:16])[CH2:5][N:6]1[CH2:11][CH2:10][C:9](=O)[CH2:8][CH2:7]1.[C:17]([O:21][C:22]([NH:24][CH2:25][CH2:26][NH2:27])=[O:23])([CH3:20])([CH3:19])[CH3:18].C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>ClCCl>[C:17]([O:21][C:22](=[O:23])[NH:24][CH2:25][CH2:26][NH:27][CH:9]1[CH2:10][CH2:11][N:6]([CH2:5][C:4]2[CH:13]=[CH:14][C:15]([Cl:16])=[C:2]([Cl:1])[CH:3]=2)[CH2:7][CH2:8]1)([CH3:20])([CH3:18])[CH3:19]

Komponenten

5

Edukt 3

HCID 187201N-BOC-ethylenediamineHCID 5049666Sodium triacetoxyborohydrideHCID 108487763,4-dichlorobenzyl-4-piperidone

Produkt 1

HCID 22396192HCID 22396192, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of the product from step (i) (1.61 g), N-(tert-butoxycarbonyl)-ethylenediamine (1 g) and sodium triacetoxyborohydride (2.12 g) in dichloromethane (20 ml) was stirred at room temperature for 3 h. The mixture was partitioned between water and ethyl acetate, the organic layer dried and evaporated under reduced pressure. Yield 1.28 g.

Aufarbeitung

  1. customThe mixture was partitioned between water and ethyl acetate
  2. customthe organic layer dried
  3. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-580f275b589746b4bc43ed6206780079
Quelldatensatz
uspto-grants-2005_06
Patentnummer
US06903085B1

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