Methanol → HCID 10237195, Verbindung

HRID 1070896Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1070896
[N+](=[CH2:3])=[N-].C(OCC)C.[C:9]([C@H:12]1[CH2:16][CH2:15][CH2:14][N:13]1[C:17](=[O:32])[CH2:18][CH2:19][CH2:20][CH2:21][C:22]([N:24]1[CH2:28][CH2:27][CH2:26][C@@H:25]1[C:29]([OH:31])=[O:30])=[O:23])(O)=[O:10].[CH3:33][OH:34]>O1CCCC1>[CH3:33][O:34][C:9]([C@H:12]1[CH2:16][CH2:15][CH2:14][N:13]1[C:17](=[O:32])[CH2:18][CH2:19][CH2:20][CH2:21][C:22]([N:24]1[CH2:28][CH2:27][CH2:26][C@@H:25]1[C:29]([O:31][CH3:3])=[O:30])=[O:23])=[O:10]

Komponenten

6

Edukt 4

HCID 887MethanolHCID 3283Diethyl EtherHCID 9550DiazomethaneHCID 125516Miridesap

Produkt 1

HCID 10237195HCID 10237195, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of diazomethane in diethylether (˜6 mmol) was added to a solution of 500 mg (1.5 mmol) (R)-1-[6-[(R)-2-carboxy-pyrrolidin-1-yl]-6-oxo-hexanoyl]-pyrrolidine-2-carboxylic acid in 10 ml tetrahydrofuran. After stirring overnight methanol was added and the solvents were evaporated. The residue was taken up in dichloromethane, extracted with brine and dried with sodium sulfate. After separation from the solvent 400 mg (72%) (R)-1-{6-[(R) -2-methoxycarbonyl-pyrrolidin-1-yl]-6-oxo-hexanoyl}-pyrrolidine-2-carboxylic acid methyl ester were obtained as a light yellow oil, MS m/e (%): 369 (M+H+, 100).

Aufarbeitung

  1. additionwas added
  2. customthe solvents were evaporated
  3. extractionextracted with brine
  4. dry with materialdried with sodium sulfate
  5. customAfter separation from the solvent 400 mg (72%) (R)-1-{6-[(R) -2-methoxycarbonyl-pyrrolidin-1-yl]-6-oxo-hexanoyl}-pyrrolidine-2-carboxylic acid methyl ester
  6. customwere obtained as a light yellow oil, MS m/e (%)

Quellen und Nachweise

ORD-Eintrag
ord-41614dc46b954e06ae130b5b54701c64
Quelldatensatz
uspto-grants-2005_06
Patentnummer
US06903129B2

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