Phenacyl bromide → 2-[Cyclopropyl-(2,4-dichloro-benzyl)-amino]-1-phenyl-ethanone

HRID 1072511Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1072511
[CH:1]1([NH:4][CH2:5][C:6]2[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:7]=2[Cl:13])[CH2:3][CH2:2]1.Br[CH2:15][C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:17].C(N(CC)CC)C.BrC1C=CC(C2C3C(=C(Cl)C=C(Cl)C=3)CN(C)C2)=CC=1>O1CCOCC1>[CH:1]1([N:4]([CH2:5][C:6]2[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:7]=2[Cl:13])[CH2:15][C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:17])[CH2:2][CH2:3]1

Komponenten

6

Edukt 4

HCID 6259Phenacyl bromideHCID 8471TriethylamineHCID 4720306Cyclopropyl-(2,4-dichloro-benzyl)-amineHCID 101772114-(4-Bromophenyl)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline

Produkt 1

HCID 223868872-[Cyclopropyl-(2,4-dichloro-benzyl)-amino]-1-phenyl-ethanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

Intermediate 1 was reacted with alpha-bromoacetophenone in the presence of triethylamine in dioxane by the method described in example 1, intermediate 3. For workup, the solvent was distilled off, and the residue was taken up in ethyl acetate. It was washed twice with H2O and twice with 2 N HCl, dried with MgSO4 and concentrated. The crude product obtained in this way was reacted further without further purification.

Aufarbeitung

  1. distillationFor workup, the solvent was distilled off
  2. washIt was washed twice with H2O and twice with 2 N HCl
  3. dry with materialdried with MgSO4
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-8cd95def416c4b37bc619ce3bc04b26b
Quelldatensatz
uspto-grants-2005_06
Patentnummer
US06911453B2

Notizen zur Reaktion

Wird geladen…