Water → HCID 22388428, Verbindung

HRID 1072780Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1072780
[CH3:1][C:2]1[C:15]([C:16]([O:18]CC)=[O:17])=[C:5]2[CH:6]=[C:7]([C:10]([O:12]CC)=[O:11])[CH:8]=[CH:9][N:4]2[N:3]=1.[OH-].[Na+].O>C(O)C>[CH3:1][C:2]1[C:15]([C:16]([OH:18])=[O:17])=[C:5]2[CH:6]=[C:7]([C:10]([OH:12])=[O:11])[CH:8]=[CH:9][N:4]2[N:3]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 22387816HCID 22387816, Verbindung

Produkt 1

HCID 22388428HCID 22388428, VerbindungAusbeute 62,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of diethyl 2-methylpyrazolo[1,5-a]pyridine-3,5-dicarboxylate (100 mg), a 50% aqueous sodium hydroxide solution (160 mg), water (0.5 ml) and ethanol (1.0 ml) was refluxed under heating for 30 min. Then, the reaction mixture was adjusted to pH 4 under ice-cooling and stirred at the same temperature for 30 min. The precipitate was collected by filtration and washed with water to give the objective compound (50 mg) as a pale-brown powder.

Aufarbeitung

  1. temperatureunder heating for 30 min
  2. temperaturecooling
  3. filtrationThe precipitate was collected by filtration
  4. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-ddc2aeace3974dd5ac14ea9b27d24d47
Quelldatensatz
uspto-grants-2005_06
Patentnummer
US06911469B2

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