Water → HCID 22388089, Verbindung

HRID 1072896Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1072896
N1C=CC=CC=1.S(Cl)([Cl:9])=O.[Cl:11][C:12]1[CH:19]=[C:18]([O:20][CH:21]([CH3:23])[CH3:22])[CH:17]=[CH:16][C:13]=1[CH2:14]O.O>ClCCl>[Cl:11][C:12]1[CH:19]=[C:18]([O:20][CH:21]([CH3:23])[CH3:22])[CH:17]=[CH:16][C:13]=1[CH2:14][Cl:9]

Komponenten

6

Edukt 4

HCID 962WaterHCID 1049PyridineHCID 24386Thionyl ChlorideHCID 22388433[2-Chloro-4-(propan-2-yloxy)phenyl]methanol

Produkt 1

HCID 22388089HCID 22388089, VerbindungAusbeute 106.483,797 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Pyridine (0.5 ml) and thionyl chloride (0.18 mg) were successively added to a solution of 2-chloro-4-isopropoxybenzylalcohol (401 mg) in dichloromethane (2 ml) under ice-cooling, and the mixture was stirred for 1 hr. Water was added to the reaction mixture and the resulting product was extracted three times with hexane. The organic layers were combined, washed successively with 1N hydrochloric acid, a saturated aqueous solution of sodium hydrogencarbonate and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated to give the objective compound (353 mg) as a yellow oil.

Aufarbeitung

  1. temperaturecooling
  2. extractionthe resulting product was extracted three times with hexane
  3. washwashed successively with 1N hydrochloric acid
  4. dry with materiala saturated aqueous solution of sodium hydrogencarbonate and saturated brine, and dried over anhydrous magnesium sulfate
  5. customThe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-39e97d12777f450aa93e0d95a2de8aa2
Quelldatensatz
uspto-grants-2005_06
Patentnummer
US06911469B2

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