Sodium Hydroxide → cis-dichloro-(3R)-3-aminopyrrolidine platinum (II)

HRID 1073312Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1073312
C([C@H]([C@@H](C(O)=O)O)O)(O)=O.[NH2:11][C@@H:12]1[CH2:16][CH2:15][NH:14][CH2:13]1.[OH-].[Na+].[Cl-:19].[K+].[Pt+2:21].[Cl-:22].[Cl-]>O>[Pt+2:21].[Cl:19][C@@H:13]1[C@H:12]([NH2:11])[CH2:16][CH2:15][N:14]1[Cl:22]

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 15107948(3R)-3-Aminopyrrolidine D(-)-tartrateHCID 86744074platinum (II) potassium chloride

Produkt 1

HCID 18640044cis-dichloro-(3R)-3-aminopyrrolidine platinum (II)Ausbeute 57,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

(3R)-3-Aminopyrrolidine D(-)-tartrate (236 mg) prepared in Reference Example 1-(1) is dissolved in water (40 ml) and thereto is added sodium hydroxide (80 mg), and the mixture is stirred at room temperature. To the solution is added platinum (II) potassium chloride (415 mg), and the mixture is stirred at room temperature overnight. The precipitated solid is removed by filtration, and the filtrate is concentrated under reduced pressure. To the residue is added water (2 ml), and the resulting crystals are separated by filtration and washed with water and acetone to give cis-dichloro-(3R)-3-aminopyrrolidine platinum (II) (200 mg) as pale yellow crystal.

Aufarbeitung

  1. stirringthe mixture is stirred at room temperature overnight
  2. customThe precipitated solid is removed by filtration
  3. concentrationthe filtrate is concentrated under reduced pressure
  4. additionTo the residue is added water (2 ml)
  5. customthe resulting crystals are separated by filtration
  6. washwashed with water and acetone

Quellen und Nachweise

ORD-Eintrag
ord-4169bbb3c4154d2ba7bf6498c53b602a
Quelldatensatz
uspto-grants-1990_11
Patentnummer
US04968800

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