Hydrochloric Acid → L-isoleucyl-L-proline benzylester hydrochloride

HRID 1073997Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1073997
[CH2:1]([O:8][C:9](=[O:30])[C@@H:10]1[CH2:14][CH2:13][CH2:12][N:11]1[C:15](=[O:29])[C@H:16]([C@H:25]([CH2:27][CH3:28])[CH3:26])[NH:17]C(OC(C)(C)C)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:31]>O1CCOCC1.C(OCC)C>[ClH:31].[CH2:1]([O:8][C:9](=[O:30])[C@@H:10]1[CH2:14][CH2:13][CH2:12][N:11]1[C:15](=[O:29])[C@H:16]([C@H:25]([CH2:27][CH3:28])[CH3:26])[NH2:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 14306235Boc-Ile-Pro-OBzl

Produkt 1

HCID 14306240L-isoleucyl-L-proline benzylester hydrochlorideAusbeute 92,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

N-t-butyloxycarbonyl-L-isoleucyl-L-proline benzylester (39.76 g, 95 mmole) was dissolved in 4N hydrochloric acid in dioxane (360 ml), and stirred for 30 minutes at room temperature. The solvent was distilled and the residue thus obtained was powdered in diethyl ether to obtain L-isoleucyl-L-proline benzylester hydrochloride(yield: 31.31 g, 92.9%).

Aufarbeitung

  1. distillationThe solvent was distilled
  2. customthe residue thus obtained

Quellen und Nachweise

ORD-Eintrag
ord-2bb9f746c0874a6a9cb3d38a698c4c84
Quelldatensatz
uspto-grants-1990_11
Patentnummer
US04971993

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