Phosphorus oxychloride → 2-Naphthalenesulfonyl chloride, 5-(acetylamino)-1-(acetyloxy)-

HRID 1075737

Reaktionsgleichung

Reaktionsgleichung von HRID 1075737
[C:1]([NH:4][C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH:7]=[CH:8][C:9]([S:19]([O-:22])(=O)=[O:20])=[C:10]2[O:15][C:16](=[O:18])[CH3:17])(=[O:3])[CH3:2].[Na+].P(Cl)(Cl)([Cl:26])=O.CNC=O>>[C:1]([NH:4][C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH:7]=[CH:8][C:9]([S:19]([Cl:26])(=[O:22])=[O:20])=[C:10]2[O:15][C:16](=[O:18])[CH3:17])(=[O:3])[CH3:2]

Komponenten

4

Edukt 3

HCID 24813Phosphorus oxychlorideHCID 31254N-MethylformamideHCID 236637052-Naphthalenesulfonic acid, 5-(acetylamino)-1-(acetyloxy)-, sodium salt (1:1)

Produkt 1

HCID 941252-Naphthalenesulfonyl chloride, 5-(acetylamino)-1-(acetyloxy)-

Versuchsvorschrift

The 5-acetamido-1-acetoxynaphthalene-2-sulfonyl chloride was prepared by dropwise treatment of a suspension of dry sodium 5-acetamido-1-acetoxynaphthalene-2-sulfonate in 100 ml. phosphoryl chloride with 5.5 ml. dry methylformamide in a nitrogen atmosphere. The reaction mixture was stirred 1 hour and then poured over 600 ml. of crushed ice. The crude product was filtered and dissolved immediately in 500 ml. chloroform. The solution was treated with activated charcoal and dried over anhydrous magnesium sulfate to give 10.8 g. (44%) of a resinous yellow product which showed a single spot on a thin-layer chromotography.

Aufarbeitung

  1. additionpoured over 600 ml
  2. filtrationThe crude product was filtered
  3. dissolutiondissolved immediately in 500 ml
  4. additionThe solution was treated with activated charcoal
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customto give 10.8 g

Quellen und Nachweise

ORD-Eintrag
ord-42c547f609ef49e793697d29c2f64f4a
Quelldatensatz
uspto-grants-1976_05
Patentnummer
US03954476

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