Hydrochloric Acid → 1-Methyl-2-nitro-1H-imidazole-5-methanol

HRID 1075967

Reaktionsgleichung

Reaktionsgleichung von HRID 1075967
[CH3:1][N:2]1[C:6]([CH:7]=[O:8])=[CH:5][N:4]=[C:3]1[N+:9]([O-:11])=[O:10].[BH4-].[Na+].Cl>C(O)C>[CH3:1][N:2]1[C:6]([CH2:7][OH:8])=[CH:5][N:4]=[C:3]1[N+:9]([O-:11])=[O:10]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 1003901-Methyl-2-nitro-1H-imidazole-5-carboxaldehydeHCID 4311764Sodium borohydride2×

Produkt 1

HCID 702921-Methyl-2-nitro-1H-imidazole-5-methanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To a solution of 1.55 g. of 1-methyl-2-nitro-5-imidazolecarboxaldehyde in 200 ml. of ethanol, a solution of 1.9 g. of NaBH4 in 150 ml. of ethanol is added at about -4° C. After stirring for 15 minutes at 0° C., the excess of NaBH4 is decomposed with 10% hydrochloric acid and the reaction mixture is filtered. the residue, which is obtained by evaporation of the filtrate, is crystallized from acetone and yield 1 g. of the title product which melts at 142°-144° C.

Aufarbeitung

  1. filtrationthe reaction mixture is filtered
  2. customthe residue, which is obtained by evaporation of the filtrate
  3. customis crystallized from acetone and yield 1 g

Quellen und Nachweise

ORD-Eintrag
ord-2ee062bf2eb644f78f5f014167135e51
Quelldatensatz
uspto-grants-1976_05
Patentnummer
US03954789

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