Carbamimidoyl-acetic acid ethyl ester → 2,6-Diamino-4-(3-carbethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Carbamimidoyl-acetic acid ethyl ester	HCID 4599837	—
Edukt	Ethyl 3-formylbenzoate	HCID 11084437	—
Lösungsmittel	Ethanol	HCID 702	—
Produkt	2,6-Diamino-4-(3-carbethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester	HCID 70631688	32%

Reaktionsschritte

Upon boiling a solution of 8.9 g 3-carbethoxybenzaldehyde and 13.0 g amidinoacetic acid ethyl ester in 100 ml ethanol for 2 hours, 2,6-diamino-4-(3-carbethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester of m.p. 191°C (ethanol) is obtained. Yield: 32% of theory.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US03957998
Quelldatensatz	uspto-grants-1976_05
ORD ID	ord-9d648254597c4ab3a7caa0055edcb69e
Quellennotiz	uspto-grants-1976_05