Hydrochloric Acid → 2,7-Bis(4-aminobutyryl)thioxanthene Dihydrochloride

HRID 1076898

Reaktionsgleichung

Reaktionsgleichung von HRID 1076898
C1(=O)[N:5]([CH2:6][CH2:7][CH2:8][C:9]([C:11]2[CH:24]=[CH:23][C:22]3[S:21][C:20]4[C:15](=[CH:16][C:17]([C:25](=[O:40])[CH2:26][CH2:27][CH2:28][N:29]5C(=O)C6=CC=CC=C6C5=O)=[CH:18][CH:19]=4)[CH2:14][C:13]=3[CH:12]=2)=[O:10])C(=O)C2=CC=CC=C12.C1(=O)N(CCCC([Cl:57])=O)C(=O)C2=CC=CC=C12.C1C2CC3C(=CC=CC=3)SC=2C=CC=1.[ClH:78]>C(O)(=O)C>[ClH:57].[ClH:78].[NH2:29][CH2:28][CH2:27][CH2:26][C:25]([C:17]1[CH:18]=[CH:19][C:20]2[S:21][C:22]3[C:13](=[CH:12][C:11]([C:9](=[O:10])[CH2:8][CH2:7][CH2:6][NH2:5])=[CH:24][CH:23]=3)[CH2:14][C:15]=2[CH:16]=1)=[O:40]

Komponenten

6

Edukt 4

HCID 313Hydrochloric Acid2×HCID 67495ThioxantheneHCID 5948864-(1,3-Dioxoisoindolin-2-yl)butanoyl chlorideHCID 21538549HCID 21538549, Verbindung

Produkt 1

HCID 215385232,7-Bis(4-aminobutyryl)thioxanthene Dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

2,7-Bis(4-phthalimidobutyryl)thioxanthene, prepared from 4-phthalimidobutyryl chloride and thioxanthene by the method of S.S. Cheng et al., J. Med. Chem. 9, 945 (1966), is treated with hot glacial acetic acid after which concentrated HCl is added gradually with stirring. The mixture is heated to reflux for 24 hours with a constant stream of HCl gas passing through the mixture. The reaction mixture is stirred and refluxed for an additional 24 hours, cooled, and the product worked up in the usual manner.

Aufarbeitung

  1. additionis added gradually
  2. temperatureThe mixture is heated
  3. stirringThe reaction mixture is stirred
  4. temperaturerefluxed for an additional 24 hours
  5. temperaturecooled

Quellen und Nachweise

ORD-Eintrag
ord-32bbde71d22946ac9780e9de7f260c7f
Quelldatensatz
uspto-grants-1976_05
Patentnummer
US03957988

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